Methoxetamine
Contents |
The Basics
Introduction and Basic Description
Methoxetamine is a dissociative anesthetic drug that was developed and marketed in the late 2000s.
Timeline of Experience
Half life is roughly 3 hours, double that of ketamine's. For rapidly absorbed routes like buccal, injected, rectal, snorted etc:
- Onset in 10-20 mins
- 1-3h main effects
- 3-6h after effects
The duration is strongly dose dependent. Large doses will leave one feeling very strange for up to 24 hours. Many users note an "afterglow" the next day.
Effects
Varied, depending on dosage. At low doses, stimulation, mood lift, increased enjoyment of music, muscular relaxation. At higher doses ataxia, dissociation, numbness, double vision, euphoria, loss of inhibitions, out of body experiences, hallucinations, time distortion. Drunken, dreamlike feeling, notably less "stoning" and immobilising than ketamine.
Dosages
Typical dosage for stimulant usage is 10-50mg, dissociative doses are closer to 100mg. 200mg insufflated or injected is bordering on overdose.
Method of administration
Snorted, injected (IM/IV), eaten (oral), rectal, smoked (as freebase). Depending on mode of administration and personal physiology, methoxetamine has varied pharmacological characteristics. It seems that injection, nasal, and rectal usage are the fastest to peak and hardest hitting. Buccal and sublingual udage is approximately 75% as efficient. Oral dosing is less effective.
Slang
"Mexi", "Minx", "Jipper"
Problems
Contraindications and Overdose
Contraindicated with other stimulants due to a tendency for mania and reckless behaviour. Alcohol, GHB, Ketamine, and other CNS depressants are likely potentiators. Some have reported bad experiences combining MXE and ketamine or alcohol.
Negative Short-Term Side Effects
Memory loss, ridiculous behaviour, panic/anxiety attacks, confusion, nausea, vomiting, tinnitus, headaches, depersonalization.
Negative Long-Term Side Effects
Dissociative toxidrome. Loss of social interaction. Possible loss of frontal lobe mass or bladder integrity. Stimulant psychosis.
Addiction and Withdrawal Issues
Psychological addiction is definitely possible, compare ketamine addiction.
Harm Reduction
Legal Issues
Possible analogue of ketamine. It is uncontrolled in the US, UK, and Canada.
Background and Chemistry
History of Drug
Chemistry
Pharmacology
NMDA receptor antagonist and dopamine reuptake inhibitor. Purportedly a ligand for the mu opiate receptor, though this is disputed.
Preparation
You wouldn't necessarily include this - possibly for drugs like crack where you have to put some effort into making them. You can include e.g. preparing ketamine powder from liquid, making crack from coke, etc. DO NOT include anything relating to synthesis! We're talking about taking a pre-existing drug and altering its form to make it easier/better to use, NOT making a drug from other chemicals.
Trip reports and links
Trip Reports
Probably a paragraph giving links to cool TRs here and on other sites. Don't re-write or copy/paste the whole trip report.
