Oxymorphone
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The Basics
Introduction and Basic Description
14-Hydroxydihydromorphinone, more commonly known as oxymorphone is an opioid analgesic, derived from the opium alkaloid Thebaine. Oxymorphone is usually used for its strong pain relieving properties as well as its high potency and euphoria.
Timeline of Experience
The timeline of experience for oxymorphone heavily depends on one's frequency of use and the route of administration (ROA).
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Unknown |
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Effects
Oxymorphone's effects are similar to other strong opiates/opioids such as oxycodone, hydromorphone and heroin. It is ten times stronger than morphine [1] (comparing the two at 100% Bioavailability's), and it's rush when injected is often compared to heroin, and sometimes preferred.
Dosages
Oxymorphone is a highly potent opioid. An opioid-naive user should begin with 2.5mg consumed orally For the more opiate experienced, it is hard to say, as it all depends on the persons tolerance, and which ROA he or she uses.
Method of administration
Oxymorphone can be injected, sniffed, plugged or taken orally. The BA for each ROA varies wildly.
Method 1
- Oral (Bioavailability of ~10%)
Method 2
- Insufflation (Bioavailability of ~50%)
Method 3
- Rectal (Bioavailability unknown, but likely comparable to intravenous)
Method 4
- Intravenous/IV (Bioavailability of 100%)
If you plan on injecting Opana (oxymorphone tablets), PLEASE use a micron filter.
Slang
Slang terms for oxymorphone include: blues, biscuits, blue heaven, new blues (although the immediate-release tablets are pink and off-white), octagons (extended release), [strength] octagons, stop signs, pink, pink heaven, biscuits (could also be Dilaudid tablets, mepro- bamate tablets, or formerly Quaaludes), pink heaven, pink lady, Mrs O, OM, Pink O, The O Bomb (by analogy to the slang term for hydromorphone "H Bomb") and others.[2]
Problems
Contraindications and Overdose
It is important for users to be aware of the potency of oxymorphone, being roughly 10x stronger than oxycodone, it can be very easy to overdose, if someone is not aware of the cross tolerant equivalencies.
Like all opiates and opioids, Oxymorphone should not be mixed with other CNS depressants (i.e. Benzodiazepines, Alchohol, Barbiturates etc..). Throwing a second CNS depressant on top of another multiplies the chances of overdose, and can be very dangerous with a drug as strong as oxymorphone.
Negative Short-Term Side Effects
- Nausea
- Miosis (Pupil constriction)
- Muscle jerks
- Mild-Severe Itching (Due to histamine release)
Negative Long-Term Side Effects
Addiction and Withdrawal Issues
Like all opiates and opioids, oxymorphone can cause physical dependance with habitual use. Acute symptoms begin within the first 24 hours since the last dose (though this time range can very drastically depending on the ROA. I.V Oxymorphone user's report feeling withdrawals as early as six hours after their last fix).
Due to it's potency, Oxymorphone withdrawal is considered especially intense, though shorter lasting than other weaker opioids such as oxycodone or morphine. Some general symptoms of Oxymorphone withdrawal are listed below:
- Runny Nose
- Diarrhea
- Sweats
- Lethargy
- Stomach Cramps
- Nausea
- Cold/Hot Flashes
- Anxiety
Harm Reduction
Legal Issues
Background and Chemistry
History of Drug
Chemistry
Pharmacology
Mechanism of Action
Trip Reports
References
(1) Eddy, Nathan B. and Lee Jr., Lyndon E. (1959). "THE ANALGESIC EQUIVALENCE TO MORPHINE AND RELATIVE SIDE ACTION LIABILITY OF OXYMORPHONE (4-HYDROXYDIHYDROMORPHINONE)." The Journal of Pharmacology and Experimental Therapeutics. http://jpet.aspetjournals.org/content/125/2/116. Retrieved 12 April 2012.
(2) Drug Enforcement Agency (2012). "Opana (Oxymorphone) Abuse." Drug Intelligence Brief. http://www.justice.gov/dea/pubs/states/phila_opana.pdf. Retrieved 12 April 2012.
